(1-Benzothiophen-3-yl)boronic acid → HCID 68426538, compound

HRID 642389Notes

Reaction equation

HRID 642389 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[S:10][C:9](Br)=[N:8][C:7]=1[CH2:12][N:13]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][C:22]=1[O:29][CH3:30])[CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:5])[CH3:2].[S:31]1[C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][C:34]=2[C:33](B(O)O)=[CH:32]1>>[CH2:1]([O:3][C:4]([C:6]1[S:10][C:9]([C:33]2[C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=3[S:31][CH:32]=2)=[N:8][C:7]=1[CH2:12][N:13]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][C:22]=1[O:29][CH3:30])[CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 2776344(1-Benzothiophen-3-yl)boronic acidHCID 684264542-Bromo-4-{[(2,4-dimethoxy-benzyl)-ethoxycarbonylmethyl-amino]-methyl}-thiazole-5-carboxylic acid ethyl ester

Product 1

HCID 68426538HCID 68426538, compound

Procedure

Prepared from 2-bromo-4-{[(2,4-dimethoxy-benzyl)-ethoxycarbonylmethyl-amino]-methyl}-thiazole-5-carboxylic acid ethy ester, example 81(b), and 1-benzothiophen-3-yl-boronic acid under conditions analogous to experimental example 81(c). MS: (+) m/z 555.5 (M+1).

Sources & evidence

ORD record
ord-763f96b983f74647ab3827c5bfc5b280
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

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