Glycine → HCID 68428236, compound

Participants

Reaction Steps

7-Cyano-2,3-dichloro-4-hydroxy-1-(3-methyl-butyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester (80 mg, 0.22 mmol) and glycine (324 mg, 4.32 mmol) were suspended in 8.64 mL of 0.5 N sodium methoxide in methanol. The reaction was heated at reflux temperature overnight, cooled, and concentrated. The residue was dissolved in water (15 mL), and the solution was acidified to pH 1-2 with 1 N hydrochloric acid. The title compound (60 mg) was collected by filtration as a light yellow solid. MS: (+) m/z 399.2 (M+1).

Provenance & Evidence