Acetic Anhydride → HCID 68426174, compound

Participants

Reaction Steps

To a solution of 7-cyano-4-hydroxy-1-(3-methyl-butyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester (0.4 g, 1.33 mmol), example 97(a), and acetic anhydride (0.25 mL, 2.65 mmol) in methylene chloride (8 mL) at ambient temperature was added triethylamine (0.37 mL, 2.65 mmol). The reaction mixture was stirred at ambient temperature for 2.5 h before 100 mL of methylene chloride was added. The organic solution was washed with 80 mL of water, dried, filtered, and concentrated. The crude product was purified by flash chromatography eluting from silica gel with a gradient of 0-50% ethyl acetate in hexanes to produce 0.44 g of a colorless oil. MS: (+) m/z 344.3 (M+1).

Provenance & Evidence