Ethyl 2-((tert-butoxycarbonyl)amino)acetate → HCID 68426364, compound

HRID 642417Notes

Reaction equation

HRID 642417 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[C:10]([Br:16])[CH:11]=[C:12]([Br:15])[CH:13]=2)[N:8]([CH3:17])[C:7]=1[CH2:18]Br)=[O:5])[CH3:2].[CH2:20]([O:22][C:23](=[O:33])[CH2:24][NH:25][C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH3:21]>>[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[C:10]([Br:16])[CH:11]=[C:12]([Br:15])[CH:13]=2)[N:8]([CH3:17])[C:7]=1[CH2:18][N:25]([C:26]([O:28][C:29]([CH3:30])([CH3:32])[CH3:31])=[O:27])[CH2:24][C:23]([O:22][CH2:20][CH3:21])=[O:33])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 357729Ethyl 2-((tert-butoxycarbonyl)amino)acetateHCID 68428467HCID 68428467, compound

Product 1

HCID 68426364HCID 68426364, compound

Procedure

Prepared in analogy to that of Example 1(c) from 5,7-dibromo-2-bromomethyl-1-methyl-1H-indole-3-carboxylic acid ethyl ester and tert-butoxycarbonylamino-acetic acid ethyl ester. The title compound, 1H NMR (200 MHz, CDCl3): δ (ppm)=8.36 (s, 1H), 7.62 (s, 1H), 5.18 (s, 2H), 4.4-3.79 (m, 8H), 1.6-1.0 (m, 15H).

Sources & evidence

ORD record
ord-141d8fea91044984919fba34b18e3670
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

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