Tributylphenyltin → HCID 68428570, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-bromo-4-hydroxy-9-methyl-9H-beta-carboline-3-carboxylic acid ethyl ester (150 mg), tributyl phenyl tin (0.169 mL), and Pd(PPh3)2Cl2 (15 mg) in DMF (1.5 mL) was heated at 120° C. for 41 min. The reaction was then partitioned between EtOAc and water, the organic phase was subsequently washed with sat. NaCl solution, dried over anhydrous sodium sulfate and then filtered, concentrated; the residue was purified with column to give the title compound (94 mg). ESI MS (m/z): 347 (M+H)+.

Provenance & Evidence