Glycine → HCID 68426164, compound

HRID 642428Notes

Reaction equation

HRID 642428 reaction equation
C(O[C:4]([C:6]1[N:18]=[C:17]([C:19]#[N:20])[C:16]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:8]=2[C:7]=1[OH:27])=[O:5])C.[NH2:28][CH2:29][C:30]([OH:32])=[O:31].C[O-].[Na+].CO>>[C:19]([C:17]1[C:16]2[C:26]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[N:9]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[C:8]=2[C:7]([OH:27])=[C:6]([C:4]([NH:28][CH2:29][C:30]([OH:32])=[O:31])=[O:5])[N:18]=1)#[N:20]

Participants

4

Reactant 3

HCID 750GlycineHCID 23694274Sodium methanolate methanolHCID 68428157HCID 68428157, compound

Product 1

HCID 68426164HCID 68426164, compound

Procedure

Prepared in analogy to that of Example 1(e) from 1-cyano-4-hydroxy-5-phenyl-5H-pyrido[4,3-b]indole-3-carboxylic acid ethyl ester, glycine and NaOMe/HOMe. The title compound, ESI MS (m/z): 385 (M−1)−.

Sources & evidence

ORD record
ord-610ca4252b92444c9491af8aad6ce5e9
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

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