Glycine → HCID 68428029, compound

HRID 642430Notes

Reaction equation

HRID 642430 reaction equation
C(O[C:4]([C:6]1[N:18]=[C:17]([CH3:19])[C:16]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:8]=2[C:7]=1[OH:26])=[O:5])C.[NH2:27][CH2:28][C:29]([OH:31])=[O:30].C[O-].[Na+].CO>>[OH:26][C:7]1[C:8]2[N:9]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=3[C:16]=2[C:17]([CH3:19])=[N:18][C:6]=1[C:4]([NH:27][CH2:28][C:29]([OH:31])=[O:30])=[O:5]

Participants

4

Reactant 3

HCID 750GlycineHCID 23694274Sodium methanolate methanolHCID 68426659HCID 68426659, compound

Product 1

HCID 68428029HCID 68428029, compound

Procedure

Prepared in analogy to that of Example 1(e) from 4-hydroxy-1-methyl-5-phenyl-5H-pyrido[4,3-b]indole-3-carboxylic acid ethyl ester, glycine and NaOMe/HOMe. The title compound, ESI MS (m/z): 376 (M+H)+.

Sources & evidence

ORD record
ord-f16ab7efbfce45039709bd1aa8f8a625
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

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