Glycine → HCID 68428592, compound

HRID 642456Notes

Reaction equation

HRID 642456 reaction equation
C(O[C:4]([C:6]1[C:7]([OH:26])=[C:8]2[C:16]([Cl:17])=[CH:15][N:14]([CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:9]2=[C:10]([C:12]#[N:13])[N:11]=1)=[O:5])C.[NH2:27][CH2:28][C:29]([OH:31])=[O:30].C[O-].[Na+].CO>>[Cl:17][C:16]1[C:8]2[C:9](=[C:10]([C:12]#[N:13])[N:11]=[C:6]([C:4]([NH:27][CH2:28][C:29]([OH:31])=[O:30])=[O:5])[C:7]=2[OH:26])[N:14]([CH2:18][CH2:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:15]=1

Participants

4

Reactant 3

HCID 750GlycineHCID 23694274Sodium methanolate methanolHCID 68426475HCID 68426475, compound

Product 1

HCID 68428592HCID 68428592, compound

Procedure

Prepared in analogy to that of Example 1(e) from 3-chloro-7-cyano-4-hydroxy-1-phenethyl-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester, glycine and NaOMe/HOMe. The title compound, ESI MS (m/z): 399 (M+H)+.

Sources & evidence

ORD record
ord-1881c16a1ca14ff8a1a95f2dd723aee3
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

Loading…