HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 642458Generated: November 2, 2026
Chlorosuccinimide → 4-Acetoxy-3-chloro-7-cyano-1-(4-fluoro-benzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester
https://huagongshe.com/reaction/642458
Participants
| Role | Name | HCID | Charge |
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| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 4-Acetoxy-7-cyano-1-(4-fluoro-benzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester | HCID 68427313 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-Acetoxy-3-chloro-7-cyano-1-(4-fluoro-benzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester | HCID 68429637 | 59.7% |
Reaction Steps
A mixture of 4-acetoxy-7-cyano-1-(4-fluoro-benzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester (103 mg), NCS (38 mg) in MeCN (2 mL) in a closed vial was heated at 90° C. for 1 h. Then the solvent was removed, the residue was purified with column to give the desired product (67 mg). The title compound, ESI MS (m/z): 416 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07696223B2 |
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| Source dataset | uspto-grants-2010_04 |
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| ORD ID | ord-c78cc4d2442d42919c3068ba96cf84a2 |
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| Source note | uspto-grants-2010_04 |
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