Glycine → HCID 42638412, compound

HRID 642460Notes

Reaction equation

HRID 642460 reaction equation
C(O[C:4]([C:6]1[C:7]([OH:26])=[C:8]2[C:16]([Cl:17])=[C:15]([Cl:18])[N:14]([CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:9]2=[C:10]([C:12]#[N:13])[N:11]=1)=[O:5])C.[NH2:27][CH2:28][C:29]([OH:31])=[O:30].C[O-].[Na+].CO>>[CH2:19]([N:14]1[C:9]2=[C:10]([C:12]#[N:13])[N:11]=[C:6]([C:4]([NH:27][CH2:28][C:29]([OH:31])=[O:30])=[O:5])[C:7]([OH:26])=[C:8]2[C:16]([Cl:17])=[C:15]1[Cl:18])[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

4

Reactant 3

HCID 750GlycineHCID 23694274Sodium methanolate methanolHCID 68428619HCID 68428619, compound

Product 1

HCID 42638412HCID 42638412, compound

Procedure

Prepared in analogy to that of Example 1(e) from 1-benzyl-2,3-dichloro-7-cyano-4-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester, glycine and NaOMe/HOMe. The title compound, ESI MS (m/z): 419 (M+H)+.

Sources & evidence

ORD record
ord-a819151e88f04c0793efc859d462f2bd
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

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