Glycine → HCID 68428981, compound

HRID 642462Notes

Reaction equation

HRID 642462 reaction equation
C(O[C:4]([C:6]1[C:7]([OH:25])=[C:8]2[C:16]([Cl:17])=[C:15]([Cl:18])[N:14]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:9]2=[C:10]([C:12]#[N:13])[N:11]=1)=[O:5])C.[NH2:26][CH2:27][C:28]([OH:30])=[O:29].C[O-].[Na+].CO>>[Cl:18][C:15]1[N:14]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:9]2=[C:10]([C:12]#[N:13])[N:11]=[C:6]([C:4]([NH:26][CH2:27][C:28]([OH:30])=[O:29])=[O:5])[C:7]([OH:25])=[C:8]2[C:16]=1[Cl:17]

Participants

4

Reactant 3

HCID 750GlycineHCID 23694274Sodium methanolate methanolHCID 68428040HCID 68428040, compound

Product 1

HCID 68428981HCID 68428981, compound

Procedure

Prepared in analogy to that of Example 1(e) from 2,3-dichloro-7-cyano-4-hydroxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester, glycine and NaOMe/HOMe. The title compound, ESI MS (m/z): 405 (M+H)+.

Sources & evidence

ORD record
ord-f4a22b2e87f84b73ad4a9df834d6769f
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

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