HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 642469Generated: October 30, 2026
N-bromobutanimide → 4-Acetoxy-1-benzyl-3-bromo-7-cyano-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester
https://huagongshe.com/reaction/642469
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 4-Acetoxy-1-benzyl-7-cyano-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester | HCID 68427851 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-Acetoxy-1-benzyl-3-bromo-7-cyano-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester | HCID 68428218 | 84.7% |
Reaction Steps
A mixture of 4-acetoxy-1-benzyl-7-cyano-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester (225 mg), NBS (116 mg) in MeCN (3 mL) in a closed vial was heated at 90° C. overnight. Then the solvent was removed, the residue was purified with column to give the desired product (232 mg). The title compound, ESI MS (m/z): 442 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07696223B2 |
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| Source dataset | uspto-grants-2010_04 |
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| ORD ID | ord-39ceac0f80ef48af84630b77e02ef5c7 |
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| Source note | uspto-grants-2010_04 |
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