HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetramethyltin → 4-Acetoxy-1-benzyl-7-cyano-3-methyl-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetramethyltin | HCID 11661 | — |
| Reactant | 4-Acetoxy-1-benzyl-3-bromo-7-cyano-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester | HCID 68428218 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Product | 4-Acetoxy-1-benzyl-7-cyano-3-methyl-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester | HCID 68427306 | — |
Reaction Steps
Prepared in analogy to a Stille methylation step in the Example 103(b) from 4-acetoxy-1-benzyl-3-bromo-7-cyano-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester, tetramethyl tin, and Pd(PPh3)2Cl2. The title compound, ESI MS (m/z): 378 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07696223B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-6561d724d7a34d09ade4dfc16614b7e0 |
| Source note | uspto-grants-2010_04 |