Glycine → HCID 68426026, compound

HRID 642488Notes

Reaction equation

HRID 642488 reaction equation
C(O[C:4]([C:6]1[C:7]([OH:26])=[C:8]2[CH:16]=[CH:15][N:14]([CH2:17][C:18]3[CH:23]=[CH:22][C:21](OC)=[CH:20]C=3)[C:9]2=[C:10]([C:12]#[N:13])[N:11]=1)=[O:5])C.[NH2:27][CH2:28][C:29]([OH:31])=[O:30].[CH3:32][O-:33].[Na+].CO>>[C:12]([C:10]1[N:11]=[C:6]([C:4]([NH:27][CH2:28][C:29]([OH:31])=[O:30])=[O:5])[C:7]([OH:26])=[C:8]2[CH:16]=[CH:15][N:14]([C:17]3[CH:18]=[CH:23][C:22]([O:33][CH3:32])=[CH:21][CH:20]=3)[C:9]=12)#[N:13]

Participants

4

Reactant 3

HCID 750GlycineHCID 23694274Sodium methanolate methanolHCID 68428970HCID 68428970, compound

Product 1

HCID 68426026HCID 68426026, compound

Procedure

Prepared in analogy to that of Example 1(e) from 7-cyano-4-hydroxy-1-(4-methoxy-benzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester, glycine and NaOMe/HOMe. The title compound, ESI MS (m/z): 367 (M+H)+.

Sources & evidence

ORD record
ord-d966b8cce0974778829ac1df793cc321
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

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