Glycine → HCID 68427947, compound

HRID 642494Notes

Reaction equation

HRID 642494 reaction equation
C([O:3][C:4]([C:6]1[C:7]([O:25]C(=O)C)=[C:8]2[C:14]([CH3:15])=[C:13]([CH3:16])[N:12]([CH2:17][C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)[C:9]2=[CH:10][N:11]=1)=O)C.[NH2:29][CH2:30][C:31]([OH:33])=[O:32].C[O-].[Na+].CO>>[F:24][C:21]1[CH:22]=[CH:23][C:18]([CH2:17][N:12]2[C:9]3=[CH:10][N:11]=[C:6]([C:4]([NH:29][CH2:30][C:31]([OH:33])=[O:32])=[O:3])[C:7]([OH:25])=[C:8]3[C:14]([CH3:15])=[C:13]2[CH3:16])=[CH:19][CH:20]=1

Participants

4

Reactant 3

HCID 750GlycineHCID 23694274Sodium methanolate methanolHCID 68426397HCID 68426397, compound

Product 1

HCID 68427947HCID 68427947, compound

Procedure

Prepared in analogy to that of Example 1(e) from 4-acetoxy-1-(4-fluoro-benzyl)-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester, glycine and NaOMe/HOMe. The title compound, ESI MS (m/z): 372 (M+H)+.

Sources & evidence

ORD record
ord-4697bee2b0b84a0d8526d46215202db0
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

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