Glycine → HCID 68428259, compound

HRID 642502Notes

Reaction equation

HRID 642502 reaction equation
C(O[C:4]([C:6]1[C:7]([O:25]C(=O)C)=[C:8]2[C:16]([Cl:17])=[CH:15][N:14]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)[C:9]2=[C:10]([C:12]#[N:13])[N:11]=1)=[O:5])C.[NH2:29][CH2:30][C:31]([OH:33])=[O:32].C[O-].[Na+].CO>>[Cl:17][C:16]1[C:8]2[C:9](=[C:10]([C:12]#[N:13])[N:11]=[C:6]([C:4]([NH:29][CH2:30][C:31]([OH:33])=[O:32])=[O:5])[C:7]=2[OH:25])[N:14]([C:18]2[CH:19]=[CH:20][C:21]([F:24])=[CH:22][CH:23]=2)[CH:15]=1

Participants

4

Reactant 3

HCID 750GlycineHCID 23694274Sodium methanolate methanolHCID 68427544HCID 68427544, compound

Product 1

HCID 68428259HCID 68428259, compound

Procedure

Prepared in analogy to that of Example 1(e) from 4-acetoxy-3-chloro-7-cyano-1-(4-fluoro-phenyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester, glycine and NaOMe/HOMe. The title compound, ESI MS (m/z): 389 (M+H)+.

Sources & evidence

ORD record
ord-3bbf7c55e5a04d1a97bae70132f19bbc
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

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