3-Methoxybenzyl chloride → HCID 68428565, compound

HRID 642512Notes

Reaction equation

HRID 642512 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7]([OH:25])=[C:8]2[C:14]([Br:15])=[C:13]([Br:16])[N:12]([CH2:17][C:18]3[CH:23]=[CH:22][C:21](F)=[CH:20][CH:19]=3)[C:9]2=[CH:10][N:11]=1)=[O:5])[CH3:2].[CH2:26]([O:28]C(C1C=CNC=1C)=O)C.COC1C=C(C=CC=1)CCl>>[CH2:1]([O:3][C:4]([C:6]1[C:7]([OH:25])=[C:8]2[C:14]([Br:15])=[C:13]([Br:16])[N:12]([CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([O:28][CH3:26])[CH:19]=3)[C:9]2=[CH:10][N:11]=1)=[O:5])[CH3:2]

Participants

4

Reactant 3

HCID 699943-Methoxybenzyl chlorideHCID 136747Ethyl 2-methyl-3-pyrrolecarboxylateHCID 598558191h-Pyrrolo[2,3-c]pyridine-5-carboxylic acid,2,3-dibromo-1-[(4-fluorophenyl)methyl]-4-hydroxy-,ethyl ester

Product 1

HCID 68428565HCID 68428565, compound

Procedure

Prepared similarly according to a reaction sequence in Example 117 steps (a), (b), (c) and (d) for the synthesis of 2,3-dibromo-1-(4-fluoro-benzyl)-4-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester starting from 2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester, 3-methoxybenzyl chloride. The title compound, ESI MS (m/z): 483 (M+H)+.

Workup

  1. customPrepared similarly

Sources & evidence

ORD record
ord-e4a2ab636c4e4addae2e083af12a0f8d
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

Loading…