Dimethylacetamide → HCID 68426259, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-bromo-1-(3-fluoro-benzyl)-4-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester (1000 mg), Zn(CN)2 (150 mg), Zn dust (17 mg), Pd2(dba)3 (59 mg), dppf (71 mg) in DMA (8 mL) was heated to 120° C. for 90 min; then the mixture was partitioned between EtOAc and water, the organic phase was then washed with sat. NaCl solution, dried over anhydrous sodium sulfate, filtered and concentrated sequentially to give a residue, which was purified with column to give desired title compound (270 mg). The title compound, ESI MS (m/z): 340 (M+H)+.

Provenance & Evidence