Glycine → HCID 68428655, compound

HRID 642530Notes

Reaction equation

HRID 642530 reaction equation
C(O[C:4]([C:6]1[C:7]([OH:25])=[C:8]2[CH:14]=[C:13]([C:15]#[N:16])[N:12]([CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=3)[C:9]2=[CH:10][N:11]=1)=[O:5])C.[NH2:26][CH2:27][C:28]([OH:30])=[O:29].C[O-].[Na+].CO>>[C:15]([C:13]1[N:12]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=2)[C:9]2=[CH:10][N:11]=[C:6]([C:4]([NH:26][CH2:27][C:28]([OH:30])=[O:29])=[O:5])[C:7]([OH:25])=[C:8]2[CH:14]=1)#[N:16]

Participants

4

Reactant 3

HCID 750GlycineHCID 23694274Sodium methanolate methanolHCID 68426259HCID 68426259, compound

Product 1

HCID 68428655HCID 68428655, compound

Procedure

Prepared in analogy to that of Example 1(e) from 2-cyano-1-(3-fluoro-benzyl)-4-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester, glycine and NaOMe/HOMe. The title compound, ESI MS (m/z): 369 (M+H)+.

Sources & evidence

ORD record
ord-bcc84b4e0cd649e1a6352de94b839c9c
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

Loading…