2,3-Dibromo-1-(3,4-difluoro-benzyl)-4-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester → 2,3-dibromo-7-cyano-1-(3,4-difluoro-benzyl)-4-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester

Participants

Reaction Steps

2,3-Dibromo-1-(3,4-difluoro-benzyl)-4-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester (4.98 g) was brominated similar to the synthesis of Example 103(a) to give the crude tribromo product, which was subjected to a cyanation condition CuCN/NMP similar to that of Example 105(a) to give the C-7 CN title product. The title compound, ESI MS (m/z): 514 (M+H)+.

Provenance & Evidence