Glycine → HCID 68428394, compound

HRID 642554Notes

Reaction equation

HRID 642554 reaction equation
C(O[C:4]([C:6]1[C:7]([OH:28])=[C:8]2[C:16]([Cl:17])=[C:15]([Cl:18])[N:14]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([F:26])=[C:22]([F:27])[CH:21]=3)[C:9]2=[C:10]([C:12]#[N:13])[N:11]=1)=[O:5])C.[NH2:29][CH2:30][C:31]([OH:33])=[O:32].C[O-].[Na+].CO>>[Cl:18][C:15]1[N:14]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([F:26])=[C:22]([F:27])[CH:21]=2)[C:9]2=[C:10]([C:12]#[N:13])[N:11]=[C:6]([C:4]([NH:29][CH2:30][C:31]([OH:33])=[O:32])=[O:5])[C:7]([OH:28])=[C:8]2[C:16]=1[Cl:17]

Participants

4

Reactant 3

HCID 750GlycineHCID 23694274Sodium methanolate methanolHCID 68427409HCID 68427409, compound

Product 1

HCID 68428394HCID 68428394, compound

Procedure

Prepared in analogy to that of Example 1(e) from 2,3-dichloro-7-cyano-1-(3,4-difluoro-benzyl)-4-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester, glycine and NaOMe/HOMe. The title compound, ESI MS (m/z): 455 (M+H)+.

Sources & evidence

ORD record
ord-59c3169470334b76a3f7b9eca2382669
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

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