Ethanol → HCID 57538790, compound

Participants

Reaction Steps

A solution of 2,2-dimethyl-thiopropionamide (7.7 g, 65.8 mmol) and ethyl 2-chloroacetate (9.26 mL, 67 mmol) in 150 mL of ethanol was heated at reflux temperature for 24 h. The reaction mixture was concentrated under reduced pressure, suspended in ethyl acetate, and washed with saturated aqueous sodium bicarbonate and brine solutions. The organic fraction was dried over anhydrous magnesium sulfate and concentrated to 14.1 g of an orange viscous material. MS (ESI+): 229.4 (M+1).

Provenance & Evidence