1-(Bromomethyl)naphthalene → HCID 58900237, compound

HRID 642613Notes

Reaction equation

HRID 642613 reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([C:14]=1[CH2:15][N:16]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH3:17])=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:5])C.Br[CH2:26][C:27]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]=[CH:29][CH:28]=1>>[CH2:18]([N:16]([CH2:15][C:14]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]([CH2:26][C:27]2[C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[CH:30]=[CH:29][CH:28]=2)[C:6]=1[C:4]([OH:5])=[O:3])[CH3:17])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 1378441-(Bromomethyl)naphthaleneHCID 68578488HCID 68578488, compound

Product 1

HCID 58900237HCID 58900237, compound

Procedure

Using general procedure B, 3-[(benzyl-methyl-amino)-methyl]-1H-indole-2-carboxylic acid ethyl ester (Lit. 4) was coupled with 1-bromomethyl-naphthalene and the product obtained was hydrolyzed to give the title compound as a pale yellow solid. MS: 433.4 ([M−H]−).

Workup

  1. customthe product obtained

Sources & evidence

ORD record
ord-286b96fc932b46f58d845d04e3c5961a
Source dataset
uspto-grants-2010_04
Patent number
US07696240B2

Reaction notes

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