1-(Bromomethyl)naphthalene → HCID 58900271, compound

HRID 642614Notes

Reaction equation

HRID 642614 reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([C:14]=1[CH2:15][N:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1)=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:5])C.Br[CH2:23][C:24]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:27]=[CH:26][CH:25]=1>>[N:16]1([CH2:15][C:14]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[N:7]([CH2:23][C:24]3[C:33]4[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=4)[CH:27]=[CH:26][CH:25]=3)[C:6]=2[C:4]([OH:3])=[O:5])[CH2:17][CH2:18][O:19][CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 1378441-(Bromomethyl)naphthaleneHCID 68580068HCID 68580068, compound

Product 1

HCID 58900271HCID 58900271, compound

Procedure

Using general procedure B, 3-morpholin-4-ylmethyl-1H-indole-2-carboxylic acid ethyl ester (Lit. 5) was coupled with 1-bromomethyl-naphthalene and the product obtained was hydrolyzed to give the title compound as a white solid. MS: 399.3 ([M−H]−).

Workup

  1. customthe product obtained

Sources & evidence

ORD record
ord-ddd0aaa0d84d4737a5655ab150001e04
Source dataset
uspto-grants-2010_04
Patent number
US07696240B2

Reaction notes

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