1-(Bromomethyl)naphthalene → HCID 58900246, compound

HRID 642634Notes

Reaction equation

HRID 642634 reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([F:15])=[C:10]([Cl:16])[CH:9]=2)=[O:5])C.Br[CH2:18][C:19]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=[CH:21][CH:20]=1>>[Cl:16][C:10]1[CH:9]=[C:8]2[C:13]([CH:14]=[C:6]([C:4]([OH:3])=[O:5])[N:7]2[CH2:18][C:19]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:22]=[CH:21][CH:20]=2)=[CH:12][C:11]=1[F:15]

Participants

3

Reactant 2

HCID 1378441-(Bromomethyl)naphthaleneHCID 18986240HCID 18986240, compound

Product 1

HCID 58900246HCID 58900246, compound

Procedure

Using general procedure B, 6-chloro-5-fluoro-1H-indole-2-carboxylic acid ethyl ester (Lit. 7) was coupled with 1-bromomethyl-naphthalene and the product obtained was hydrolyzed to give the title compound as a white solid. MS: 352.0 ([M−H]−).

Workup

  1. customthe product obtained

Sources & evidence

ORD record
ord-54717a903ba4459d91522bb1e4c2ece0
Source dataset
uspto-grants-2010_04
Patent number
US07696240B2

Reaction notes

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