1-(Bromomethyl)naphthalene → HCID 58900288, compound

HRID 642636Notes

Reaction equation

HRID 642636 reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([C:14]=1[O:15][CH3:16])=[CH:12][C:11]([Cl:17])=[CH:10][CH:9]=2)=[O:5])C.Br[CH2:19][C:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[CH:22][CH:21]=1>>[Cl:17][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:19][C:20]1[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH:23]=[CH:22][CH:21]=1)[C:6]([C:4]([OH:3])=[O:5])=[C:14]2[O:15][CH3:16]

Participants

3

Reactant 2

HCID 1378441-(Bromomethyl)naphthaleneHCID 10706069Ethyl 5-chloro-3-methoxy-1H-indole-2-carboxylate

Product 1

HCID 58900288HCID 58900288, compound

Procedure

Using general procedure B, 5-chloro-3-methoxy-1H-indole-2-carboxylic acid ethyl ester (Lit. 9) was coupled with 1-bromomethyl-naphthalene and the product obtained was hydrolyzed to give the title compound as a white solid. MS: 364.1 ([M−H]−).

Workup

  1. customthe product obtained

Sources & evidence

ORD record
ord-812e98e6c52c41e987069bda2001b3ff
Source dataset
uspto-grants-2010_04
Patent number
US07696240B2

Reaction notes

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