Ethyl indole-2-carboxylate → HCID 58900299, compound

HRID 642649Notes

Reaction equation

HRID 642649 reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:5])C.Cl[CH2:16][C:17]1[C:26]2[C:21](=[CH:22][C:23]([O:29][CH3:30])=[C:24]([O:27][CH3:28])[CH:25]=2)[CH:20]=[CH:19][CH:18]=1>>[CH3:30][O:29][C:23]1[CH:22]=[C:21]2[C:26](=[CH:25][C:24]=1[O:27][CH3:28])[C:17]([CH2:16][N:7]1[C:8]3[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=3)[CH:14]=[C:6]1[C:4]([OH:3])=[O:5])=[CH:18][CH:19]=[CH:20]2

Participants

3

Reactant 2

HCID 73125Ethyl indole-2-carboxylateHCID 12849303HCID 12849303, compound

Product 1

HCID 58900299HCID 58900299, compound

Procedure

Using general procedure B, 1H-indole-2-carboxylic acid ethyl ester was coupled with 1-chloromethyl-6,7-dimethoxy-naphthalene (Lit. 11) and the product obtained was hydrolyzed to give the title compound as a pale yellow solid. MS: 360.0 ([M−H]−).

Workup

  1. customthe product obtained

Sources & evidence

ORD record
ord-6cad83c895d74e5580acce58b32dcdd9
Source dataset
uspto-grants-2010_04
Patent number
US07696240B2

Reaction notes

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