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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 642673Generated: October 30, 2026

Ethyl indole-2-carboxylate → 1-Benzofuran-3-ylmethyl-1H-indole-2-carboxylic acid

https://huagongshe.com/reaction/642673

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl indole-2-carboxylateHCID 73125—
Reactant3-(Bromomethyl)-1-benzofuranHCID 12337497—
Product1-Benzofuran-3-ylmethyl-1H-indole-2-carboxylic acidHCID 58900253—

Reaction Steps

Using general procedure B, 1H-indole-2-carboxylic acid ethyl ester was coupled with 3-bromomethyl-benzofuran (Lit. 19) and the product obtained was hydrolyzed to give the title compound as a white solid. MS: 290.2 ([M−H]−).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07696240B2
Source datasetuspto-grants-2010_04
ORD IDord-947feb824466429bbd46cde81b879ea7
Source noteuspto-grants-2010_04