Ethyl 5-methylindole-2-carboxylate → 1-(7-fluoro-naphthalen-1-ylmethyl)-5-methyl-1H-indole-2-carboxylic acid ethyl ester

Participants

Reaction Steps

Using general procedure B, 5-methyl-1H-indole-2-carboxylic acid ethyl ester was coupled with 1-bromomethyl-7-fluoro-naphthalene (from Example 49.3.) to give 1-(7-fluoro-naphthalen-1-ylmethyl)-5-methyl-1H-indole-2-carboxylic acid ethyl ester which was hydrolyzed as described in the general procedure B (Exp. 2.2) to give the title compound as a white solid. MS: 332.3 ([M−H]−).

Provenance & Evidence