HuagongsheHuagongshe Chemistry Print Report · For research reference only
ethyl 5-fluoro-3-formyl-1H-indole-2-carboxylate → 5-fluoro-1-(5-fluoro-benzo[b]thiophen-3-ylmethyl)-3-formyl-1H-indole-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | ethyl 5-fluoro-3-formyl-1H-indole-2-carboxylate | HCID 4352190 | — |
| Reactant | 3-(Bromomethyl)-5-fluoro-1-benzothiophene | HCID 13642592 | — |
| Product | 5-fluoro-1-(5-fluoro-benzo[b]thiophen-3-ylmethyl)-3-formyl-1H-indole-2-carboxylic acid ethyl ester | HCID 86613197 | — |
Reaction Steps
Using general procedure B, 5-fluoro-3-formyl-1H-indole-2-carboxylic acid ethyl ester was coupled with 3-bromomethyl-5-fluoro-benzo[b]thiophene (Lit. 18) to give 5-fluoro-1-(5-fluoro-benzo[b]thiophen-3-ylmethyl)-3-formyl-1H-indole-2-carboxylic acid ethyl ester as white solid. MS: 400.1 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07696240B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-3f144c7a7b174ba390f561bc684ae216 |
| Source note | uspto-grants-2010_04 |