HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → (6-Carboxyhexyl)triphenylphosphonium bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 6-Bromohexanoic acid | HCID 20210 | — |
| Product | (6-Carboxyhexyl)triphenylphosphonium bromide | HCID 11027094 | 86% |
Reaction Steps
A solution of 6-bromohexanoic acid (18 mmol, 3.50 g) and triphenylphosphine (18 mmol, 4.71 g) in acetonitrile (18 mL) was refluxed for 18 h. The reaction mixture was then cooled down, the off-white solid formed filtered. Flash chromatography over silica gel (EtOAc then MeOH) afforded the product as a white solid (1.08 g, 86%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07696243B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-1538583ab7674b6b84b4c68a1c868f6b |
| Source note | uspto-grants-2010_04 |