反应详情

To a solution of 2,6-dimethyl-4-nitro-4′-trifluoromethyl-biphenyl (0.68 g) in ethanol (20 mL) is added 10% palladium on carbon (0.02 g). The reaction is charged to 30 psi under a hydrogen atmosphere and allowed to stir for 4 h. The mixture is then filtered through a pad of Celite®. The solution is concentrated and purified by reverse phase HPLC using 0.1% TFA in water and acetonitrile to afford 0.63 g of the titled compound. 1H-NMR.

1. additionThe reaction is charged to 30 psi under a hydrogen atmosphere
2. filtrationThe mixture is then filtered through a pad of Celite®
3. concentrationThe solution is concentrated
4. custompurified by reverse phase