HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyl-4-(hydroxymethyl)piperidin-4-ol → 4-(Hydroxymethyl)piperidin-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyl-4-(hydroxymethyl)piperidin-4-ol | HCID 14025336 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(Hydroxymethyl)piperidin-4-ol | HCID 22744473 | — |
Reaction Steps
A suspension of 26.0 g (117 mmol) 1-benzyl-4-hydroxymethyl-piperidin-4-ol and 5.0 g 10% Pd/C in 500 mL MeOH was hydrogenated at 50° C. and 3 bar hydrogen pressure until the theoretical hydrogen uptake had occurred (4 h). The catalyst was filtered off and washed with MeOH. After the solvent had been eliminated the residue was reacted further without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07696195B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-296e78c1935344c180208533e9baa118 |
| Source note | uspto-grants-2010_04 |