Citric Acid → HCID 57847791, compound

HRID 642834Notes

Reaction equation

HRID 642834 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([CH3:14])[C:11]=1[O:12]C)[C:6]([OH:8])=[O:7].Cl.N1C=CC=CC=1.C(O)(=O)CC(CC(O)=O)(C(O)=O)O>>[OH:2][C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([CH3:14])[C:11]=1[OH:12])[C:6]([OH:8])=[O:7]

Participants

4

Reactant 3

HCID 311Citric AcidHCID 10176127Pyridinium chlorideHCID 231166303,4-Dimethoxy-5-methylbenzoic acid

Product 1

HCID 57847791HCID 57847791, compound

Procedure

Under a nitrogen atmosphere 50.0 g (0.25 mol) 3,4-dimethoxy-5-methyl-benzoic acid and 170 g pyridine-hydrochloride were stirred for 2 h at a bath temperature of 160° C. The reaction mixture was poured onto 1 L citric acid solution and extracted with 1 L EtOAc. The organic phase was washed with 1 L water, dried and evaporated down i.vac.

Workup

  1. extractionextracted with 1 L EtOAc
  2. washThe organic phase was washed with 1 L water
  3. customdried
  4. customevaporated down i.vac

Sources & evidence

ORD record
ord-43b3fa54b63b4e3d9750ef92be2fcd57
Source dataset
uspto-grants-2010_04
Patent number
US07696195B2

Reaction notes

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