Lithium Hydroxide → HCID 11643366, compound

Participants

Reaction Steps

A solution of 1.4 mg (0.06 mmol) LiOH in 0.5 mL water was added to a solution of 28 mg (0.04 mmol) (R)-2-(1′-ethoxycarbonylmethyl-4,4′-bipiperidinyl-1-yl)-1-(8-methyl-2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-2-oxo-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate (Example 6.5) in 0.5 mL THF and the reaction solution was stirred for 3 h at RT. The reaction mixture was purified by HPLC without any further working up. The fractions containing the product were combined and lyophilised.

Provenance & Evidence