Dichloromethane → L-Phenylalanine, methyl ester

Participants

Reaction Steps

L-Phenylalanine methyl ester hydrochloride (4.9 g) was dissolved in water (25 mL) in a 100 mL round bottom flask and stirred at room temperature. Sodium carbonate (3.1 g) in water (12.5 mL) was added in 3 minutes. The reaction mixture was stirred for 5 minutes at room temperature. Dichloromethane (25 mL) was added and the reaction mixture was stirred 5 minutes. The aqueous solution was transferred to a 125 mL separating funnel. The organic layer was collected. The aqueous layer was extracted twice with 12.5 mL of dichloromethane. The three organic extractions were combined, dried with magnesium sulfate (6 g), filtered to remove the magnesium sulfate and concentrated to give L-phenylalanine methyl ester free base.

Provenance & Evidence