Diisopropylethylamine → HCID 68577471, compound

Participants

Reaction Steps

0.069 ml (0.522 mmol) of 4-fluorophenyl chloroformate and 0.149 ml (0.82 mmol) of N,N-diisopropylethylamine are added, dropwise and at ambient temperature, to a solution of 0.107 g (0.58 mmol) of 4-phenylbenzylamine in 4 ml of methylene chloride. The mixture is stirred at ambient temperature for 1 h. The reaction medium is diluted with a further 2 ml of methylene chloride and washed with a saturated aqueous ammonium chloride solution and with a saturated aqueous sodium chloride solution. The phases are separated and the organic phase is filtered through a hydrophobic sintered glass funnel. The filtrate is concentrated under reduced pressure and the solid residue is washed with 5 ml of diisopropyl ether.

Provenance & Evidence