Water → HCID 59260059, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 2-(4-iodophenyl)-1H-imidazole-4-carboxylic acid prepared above (257 mg, 0.818 mmol) and NaH (60% suspension, washed with hexane, 82 mg, 2.1 mmol) in DMF (8 mL) was added iodomethane (0.130 mL, 2.1 mmol). The mixture was heated at 50° C. for 2 h. More iodomethane (0.100 mL) was added to the reaction mixture. After being stirred at 50° C. for an additional 2 h, water and EtOAc were added. The organic layer was separated, dried over Na2SO4, concentrated in vacuo to give methyl 2-(4-iodophenyl)-1-methyl-1H-imidazole-4-carboxylate (152 mg). MS 342.8 (M+H).

Provenance & Evidence