5-Chloro-2-thiophenecarboxylic acid → HCID 59260114, compound

Participants

Reaction Steps

To a solution of 5-chloro-thiophene-2-carboxylic acid (23 mg, 0.14 mmol), (2-(4-iodophenyl)-1-methyl-1H-imidazol-4-yl)methyl amine prepared above (21 mg, 0.067 mmol) and TEA (0.050 mL, 0.36 mmol) in DMF (2 mL) was added BOP (70 mg, 0.16 mmol). The mixture was stirred at room temperature overnight. It was then purified by HPLC to give 5-chloro-N-((2-(4-iodophenyl)-1-methyl-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide (14 mg). MS 457.9 and 459.9 (M+H).

Provenance & Evidence