HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-Chloro-N-((1-(4-iodophenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 5-Chloro-2-thiophenecarboxylic acid | HCID 95048 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | 4-Aminomethyl 1-(4-iodophenyl)imidazole | HCID 59260109 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-Chloro-N-((1-(4-iodophenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide | HCID 24986897 | 97.2% |
Reaction Steps
To a mixture of 5-chlorothiophene-2-carboxylic acid (0.346 g, 2.13 mmol), (1-(4-iodophenyl)-1H-imidazol-4-yl)methanamine 9.7 (0.578 g, 1.93 mmol) and TEA (0.670 mL, 4.82 mmol) in DMF (10 mL), BOP (1.03 g, 2.33 mmol) was added. The mixture was then stirred at room temperature overnight. Water and EtOAc were added. The organic layer was separated, washed with 5% NaHCO3, dried over Na2SO4, concentrated in vacuo to give the title compound as a solid (0.832 g). MS found for C15H11ClIN3OS: 443.9 and 445.9 ((M+H)+, Cl pattern).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07696352B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-457a9dffa60a47b6afb1fc43b9c37483 |
| Source note | uspto-grants-2010_04 |