(2-Methoxypyridin-3-yl)boronic acid → HCID 86614001, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-chloro-N-((1-(4-iodophenyl-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide (0.044 g, 0.1 mmol), 2-methoxypyridine-3-ylboronic acid (0.016 g, 0.11 mmol) and Pd(PPh3)2Cl2 (0.007 g, 0.01 mmol) in p-dioxane (0.7 mL) was purged with Argon for 5 min. A degassed aqueous solution of Na2CO3 (IM, 0.3 mL) was added. After being heated at 100° C. for 2 h, the mixture was cooled to room temperature, and purified by preparative HPLC to yield 5-chloro-N-((1-(4-(2-methoxypyridin-3-yl)phenyl-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide (MS 425.0, 427.0 (M+H), Cl pattern).

Provenance & Evidence