Sodium Iodide → HCID 86614003, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-chloro-N-((1-(4-(2-methoxypyridin-3-yl)phenyl-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide (0.01 g, 0.024 mmol) in AcCN (1 mL) was added NaI (0.011 g, 0.072 mmol) and TMSCl (0.045 mL, 0.36 mmol). After heating at 80° C. for 90 min, the reaction mixture was cooled to room temperature, and purified by preparative HPLC to yield 5-chloro-N-((1-(4-(2-oxo-1,2-dihydropyridin-3-yl)phenyl-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide (MS 411.0, 413.0 (M+H) Cl pattern).

Provenance & Evidence