Methyl iodide → HCID 86614004, compound

Participants

Reaction Steps

To a solution of 5-chloro-N-((1-(4-(2-oxo-1,2-dihydropyridin-3-yl)phenyl-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide (0.02 g, 0.05 mmol) in DMF (0.5 mL) was added Cs2CO3 (0.049 g, 0.15 mmol) and MeI (0.01 mL, 0.15 mmol). After stirring for 30 min at ambient temperature, the mixture was purified by preparative HPLC to give 5-chloro-N-((1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-3-yl)phenyl-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide (MS 425.1, 427.1 (M+H) Cl pattern).

Provenance & Evidence