HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 643005Generated: October 31, 2026
Water → 1-(5-bromopyridin-2-yl)-1H-imidazole-4-carbaldehyde
https://huagongshe.com/reaction/643005
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1H-Imidazole-4-carbaldehyde | HCID 76428 | — |
| Reactant | 5-Bromo-2-fluoropyridine | HCID 2783168 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(5-bromopyridin-2-yl)-1H-imidazole-4-carbaldehyde | HCID 86614005 | 81.8% |
Reaction Steps
A mixture of 5-bromo-2-fluoropyridine (630 mg, 3.58 mmol), 4-imidazolecarboxaldehyde (355 mg, 3.70 mmol) and K2CO3 (1.00 g, 7.25 mmol) in DMF (10 mL) was stirred at 70° C. overnight. After being cooled down, H2O was added to induce precipitation. The precipitate was collected and dried on vacuum to give 1-(5-bromopyridin-2-yl)-1H-imidazole-4-carbaldehyde (738 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07696352B2 |
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| Source dataset | uspto-grants-2010_04 |
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| ORD ID | ord-ac78f3b6ccee49ee9a3e7117e48e8926 |
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| Source note | uspto-grants-2010_04 |
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