Formaldehyde → HCID 24989849, compound

Participants

Reaction Steps

5-Chloro-N-((1-(4-(2-oxopiperazin-1-yl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)thiophene-2-carboxamide (24 mg, 0.06 mmol, prepared as shown in Example 60) was stirred in 2 mL acetic acid at RT. To it was added formaldehyde (37% in water, 22 μL, 0.3 mmol). The mixture was stirred for 10 min. NaBH3CN (30 mg, 0.48 mmol) was added. The reaction was allowed for 10 min, and directly subjected to reverse phase prep HPLC to isolate the title compound. MS found for C19H19ClN6O2S (M+H)+ 431.1, 433.1 (Cl pattern).

Provenance & Evidence