HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(azidomethyl)-1-(4-iodophenyl)-1H-pyrazole → (1-(4-iodophenyl)-1H-pyrazol-4-yl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(azidomethyl)-1-(4-iodophenyl)-1H-pyrazole | HCID 86614008 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (1-(4-iodophenyl)-1H-pyrazol-4-yl)methanamine | HCID 68507921 | 81.2% |
Reaction Steps
A mixture of 4-(azidomethyl)-1-(4-iodophenyl)-1H-pyrazole (530 mg, 1.63 mmol) and Ra—Ni (50% aq. slurry, 200 mg) in MeOH (3 mL) was hydrogenated under balloon H2 for 1 hr. It was filtered through celite. The filtrate was concentrated in vacuo to give (1-(4-iodophenyl)-1H-pyrazol-4-yl)methanamine (396 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07696352B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-9d927dbb347f4c57b57d9a8092397621 |
| Source note | uspto-grants-2010_04 |