Ammonia → HCID 67524216, compound

HRID 643049Notes

Reaction equation

HRID 643049 reaction equation
C[O:2][C:3](=O)[CH2:4][CH2:5][CH2:6][CH:7]=[CH:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15](=[O:21])[NH:16][CH:17]([CH3:20])[CH2:18][OH:19])[CH:10]=1.[NH3:23]>O>[C:3]([CH2:4][CH2:5][CH2:6][CH:7]=[CH:8][C:9]1[CH:10]=[C:11]([CH:12]=[CH:13][CH:14]=1)[C:15]([NH:16][CH:17]([CH3:20])[CH2:18][OH:19])=[O:21])(=[O:2])[NH2:23]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 67524123HCID 67524123, compound

Product 1

HCID 67524216HCID 67524216, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

21 (0.030 g, 0.10 mmol) was dissolved in 2 mL of ammonia 33% solution in water and stirred at room temperature for 8 h. The solvent was removed and the product was purify by reverse-phase HPLC chromatography (18% acetonitrile/82% water 20 min isocratic program) to give 19 (7 mg).

Workup

  1. customThe solvent was removed
  2. customthe product was purify by reverse-phase HPLC chromatography (18% acetonitrile/82% water 20 min isocratic program)

Sources & evidence

ORD record
ord-90415631b05544c685a1461179628aa0
Source dataset
uspto-grants-2010_04
Patent number
US07696382B2

Reaction notes

Loading…