HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ethyl 1-benzyl-4-hydrazinylpiperidine-4-carboxylate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl 1-benzyl-4-(N,N'-di-tert-butyloxycarbonylhydrazino)piperidin-4-ylcarboxylate | HCID 15663644 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Ethyl 1-benzyl-4-hydrazinylpiperidine-4-carboxylate hydrochloride | HCID 117668154 | 88.9% |
Reaction Steps
A mixture of di-tert-butyl 1-(1-benzyl-4-(ethoxycarbonyl)piperidin-4-yl)hydrazine-1,2-dicarboxylate (1.0 g, 2.09 mmol) and con. HCl (1.0 mL) in MeOH (10 mL) was heated to reflux for 2 hr. The mixture was then concentrated to give the crude product (650 mg, 88.9%) as a yellow solid. MS (ESI, m/e) [M+1]+ 278.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09447106B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-30db4601f7734b269e36785a41fea959 |
| Source note | uspto-grants-2016_09 |