HCID 67524990, compound → HCID 67525403, compound

HRID 643050Notes

Reaction equation

HRID 643050 reaction equation
[CH3:1][N:2]([CH3:23])[C:3]([CH:5](C)[CH2:6][C:7]#[C:8][C:9]1[CH:10]=[C:11]([CH:19]=[CH:20][CH:21]=1)[C:12]([NH:14][CH:15]([CH3:18])[CH2:16][OH:17])=[O:13])=[O:4]>[Ni]>[CH3:23][N:2]([CH3:1])[C:3]([CH2:5][CH2:6][CH:7]=[CH:8][C:9]1[CH:10]=[C:11]([CH:19]=[CH:20][CH:21]=1)[C:12]([NH:14][CH:15]([CH3:18])[CH2:16][OH:17])=[O:13])=[O:4]

Participants

3

Reactant 1

HCID 67524990HCID 67524990, compound

Product 1

HCID 67525403HCID 67525403, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

Hydrogenation of the alkyne 9 (0.055 g, 0.18 mmol) using BER/Ni catalyst gave 40% 27, 5% of the saturated compound and 55% of starting material. The mixture was separated by reverse-phase HPLC chromatography (20% acetonitrile/80% water 20 min isocratic program) to give 27 (15 mg).

Sources & evidence

ORD record
ord-ff47b86e39434737ba5846d470f7eaf3
Source dataset
uspto-grants-2010_04
Patent number
US07696382B2

Reaction notes

Loading…