HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → HCID 28833066, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | 4-(Chloromethyl)-2-methyl-1,3-thiazole | HCID 736341 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 28833066 | HCID 28833066 | 85% |
Reaction Steps
2-Methyl-4-(chloromethyl)thiazole (2.24 g) was treated with ethanolamine (11.6 mL, 10 equivalents) in dichloromethane at 25° C. for 16 hrs. The solvent was evaporated and the residue partitioned between ethyl acetate and brine. The organic layer was separated and extracted with ethyl acetate (5×). The organic layers were combined and washed with brine, dried over Na2SO4, and the solvents were evaporated to give 2.4 g (85%) of title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07696226B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-284159ee40b045c5aefbde2b7eedfba9 |
| Source note | uspto-grants-2010_04 |